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Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach Free
Shigeo Masuda1, Jun Wu1, Tomoaki Hishida1, Ganesh N. Pandian2, Hiroshi Sugiyama2,3, and Juan Carlos Izpisua Belmonte1,4,*
1Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
2Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto 606-8502, Japan
3Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan
4Center of Regenerative Medicine in Barcelona, Dr Aiguader 88, 08003 Barcelona, Spain
*Correspondence to:Juan Carlos Izpisua Belmonte, E-mail: belmonte@salk.edu, izpisua@cmrb.eu
J Mol Cell Biol, Volume 5, Issue 5, October 2013, 354-355,  https://doi.org/10.1093/jmcb/mjt034

Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.


Volume 5, Issue 5
October 2013